Senology.org - Newsletter

International Senologic and Oncologic  Scientific Community (ISOSC) 

"Connecting specialists worldwide"

February 25, 2014

Editor-in-Chief: Gian Paolo Andreoletti, MD

 

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FOCUS ON  - Choosing the appropriate contrast agent for breast MRI - in collaboration with Bracco Imaging

"The significantly increased value of the higher-relaxivity MR contrast agent MultiHance relative to Magnevist for the detection and characterization of breast cancer on MRI has previously been demonstrated by Pediconi et al. in two single-center intra-individual crossover studies (1, 2) and most recently by Martincich et al. in a much larger multi-center crossover study involving 151 patients who each received identical 0.1 mmol/kg bodyweight doses of each agent in two otherwise identical breast MRI examinations (3). In this latter study ...(read more)"

 

 

Literature Selection

Editorial

  • "Prognostic significance of androgen receptor expression in breast cancer" Alberto Ocana Fernandez, Medical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain
     
    "The androgen receptor is expressed frequently in breast cancer, but its prognostic significance is unclear.  To address this issue we performed a systematic review of electronic databases to identify studies published between 1946 and July 2012, that included nineteen studies with a total of 7693 women. 60.5% of breast cancer patients expressed the androgen receptor. Estrogen receptor-positive tumors were more likely to express the androgen receptor. Expression of this receptor were associated with improved overall survival (OS) at both 3 and 5 years. In conclusion the expression of the androgen receptor in women with breast cancer is associated with better overall survival and disease free survival irrespective of coexpression of ER. Ongoing studies are evaluating the role of targetting this receptor in different breast cancer subtypes”.
    (Commentary on: 
    Vera-Badillo FE et al.: "Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis", J Natl Cancer Inst. 2014 Jan 1;106(1):djt319)

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