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Prognostic significance
of androgen receptor expression in breast cancer
The
androgen receptor is expressed frequently in breast cancer, but
its prognostic significance is unclear. To address this
issue we performed a systematic review of electronic databases
to identify studies published between 1946 and July 2012,
that included nineteen studies with a total of 7693 women.
60.5%
of breast cancer patients expressed the androgen receptor.
Estrogen
receptor-positive tumors were more likely to express the
androgen receptor. Expression
of
this
receptor
were
associated with improved overall survival (OS) at both 3 and 5
years. In conclusion the expression
of the androgen receptor in
women with breast cancer is associated with better overall
survival and
disease free survival irrespective of coexpression of ER.
Ongoing studies are evaluating the role of targetting this
receptor in different breast cancer subtypes.
Bibliographic Reference:
Alberto
Ocana Fernandez
Medical
Oncology Department and Translational Research Unit, Albacete
University Hospital, Albacete, Spain
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