ONCOMETABOLOGY

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WHAT IF CANCER ORIGINATED PRIMARILY FROM SYSTEMIC METABOLISM, NOT FROM THE TUMOR CELL?
#ONCOMETABOLOGY

Cancer has traditionally been viewed through a reductionist lens, as a disease caused by genetic mutations that alter cellular signaling and lead to uncontrolled proliferation.

Yet, in the last two decades, a more complex vision has emerged: cancer is not only a genetic disorder but also a systemic one.

It develops and thrives within an organism influenced by metabolism, immunity, chronic inflammation, neuroendocrine signaling, microbiota, lifestyle, and environmental exposures.

This multifactorial reality underscores the limitations of an exclusively gene-centered view and highlights the need for a more integrative framework.

Oncometabology, a new multidisciplinary branch of Oncology created by the "International Senology Oncology Scientific Community (ISOSC)" in July 2025, is proposed as such a framework.

At its heart lies the recognition that low-grade chronic inflammation (LGCI) is a central driver linking cancer to stress, obesity, diabetes, cardiovascular disease, neurodegeneration, and aging.

Gian Paolo Andreoletti - Oncologist, Medical Journalist
President of the International Senology Oncology Scientific Community (ISOSC)
Founder of the Oncometabology Project

• Oncometabology Manifesto
  https://www.researchgate.net/publication/393788528_ONCOMETABOLOGY_-_MANIFESTO_Andreoletti_Gian_Paolo?channel=doi&linkId=687a0c93ba8eac4f17276edf&showFulltext=true
• Oncometabology: A New Multidisciplinary Paradigm in Oncology
  https://www.researchgate.net/publication/395789218_Oncometabology_A_New_Multidisciplinary_Paradigm_in_Oncology?channel=doi&linkId=68d3dce39383755fd705cc8a&showFulltext=true
• Oncometabology Project: Future Prospects - Pathophysiological Bases of Oncometabology
  https://www.researchgate.net/publication/395334894_ONCOMETABOLOGY_PROJECT_Future_Prospects_Pathophysiological_Bases_of_Oncometabology?channel=doi&linkId=68bd5c3573c8345b7a5a6111&showFulltext=true
• Future Prospects: Oncometabology and the Oncometabologist
  https://www.researchgate.net/publication/395592675_Future_Prospects_Oncometabology_and_the_Oncometabologist?channel=doi&linkId=68cc127911d348252ba62ad0&showFulltext=true
• What if cancer originated primarily from systemic metabolism, not from the tumor cell?
  https://www.linkedin.com/feed/update/urn:li:activity:7382788842736648192?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAVxcB8B0JRdTahOkFD-5Ws4ssQAp5BptdQ
• The 7 Thematic Macro-Areas of Oncometabology
  https://www.linkedin.com/posts/gianpaolo-andreoletti-5136bb26_what-if-cancer-originated-primarily-from-activity-7383777793752469504-sFNm?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAVxcB8B0JRdTahOkFD-5Ws4ssQAp5BptdQ
• The new ACC (American College of Cardiology) Statement as inspiration for Oncometabology in the Oncology field
  https://lnkd.in/dmYhdaCA
• Oncometabology and Win-Win Initiative: Two Complementary Projects for a More Sustainable Future of Oncology
  https://lnkd.in/dJMgksmp
• Cancer and other Diseases associated with Chronic Inflammation: ONCOMETABOLOGY and MULTIDISCIPLINARITY
  https://www.linkedin.com/posts/gianpaolo-andreoletti-5136bb26_oncometabology-activity-7397906699803676673-1KhS?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAVxcB8B0JRdTahOkFD-5Ws4ssQAp5BptdQ
• Metabolismo, Obesità e Cancro: un nuovo Asse per la Prevenzione - Interview
  https://www.linkedin.com/feed/update/urn:li:activity:7401887501814059008?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAVxcB8B0JRdTahOkFD-5Ws4ssQAp5BptdQ
• From multidisciplinary evidence to a systemic metabolic paradigm in Oncology
  https://www.linkedin.com/posts/gianpaolo-andreoletti-5136bb26_oncometabology-activity-7404471498515804160-N764?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAVxcB8B0JRdTahOkFD-5Ws4ssQAp5BptdQ

For further discussion and resources on Oncometabology research topics, you are welcome to join our LinkedIn communities:

ISOSC - International Senology Oncology Scientific Community https://www.linkedin.com/groups/3660202/

ICO - International Community of Oncometabology https://www.linkedin.com/groups/10149219

GIO - Gruppo Italiano di Oncometabologia https://www.linkedin.com/groups/10146273/

Oncometabology Project https://www.linkedin.com/groups/10180052/