"Triple negative breast
cancer (TNBC) demonstrates poor prognosis because of aggressive tumor
biology and lack of targeted agents.
TNBC with high Ki-67 was associated with a more aggressive clinical
feature despite a higher pCR rate. Ki-67 can be used for further
classification of TNBC into two subtypes with different prognosis. Our
report suggests that TNBC with residual disease and high Ki-67 expression
should be a candidate for additional postoperative treatment such as
platinum-based chemotherapy, or clinical trials specifically testing novel
therapies in order to improve the outcome for this high-risk group of
patients. In addition, TNBC with high Ki-67 should be followed-up more
frequently within 3 years to guard for any recurrence" (Comment
on: Keam
B et al.: "Ki-67 can be used for further classification of
triple negative breast cancer into two subtypes with different
response and prognosis", Breast
Cancer Res. 2011 Mar 2;13(2):R22. [Epub ahead of print])
In
1874 the British surgeon and pathologist James Paget
makes a brief report describing changes on the nipple that
precede the manifestation of breast cancer (Paget’s disease of
the nipple)
"What do you think about intraoperative radiotherapy
(IORT) in the treatment of cancer?" - Share
your opinion on LinkedIn®.
Read a comment from Michael Baum, University
College London, London, UK
"What do you think about intraoperative radiotherapy
(IORT) in the treatment of cancer?"
"
