Editor-in-chief: Gian Paolo Andreoletti, MD

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Best Studies of the Month

• Yaffe MJ et al.: "Risk of Radiation-induced Breast Cancer from Mammographic Screening", Radiology. 2010 Nov 16. [Epub ahead of print]
• Cuzick J et al.: "Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial", Lancet Oncol. 2010 Nov 16. [Epub ahead of print]

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Literature Selection

• Dorgan JF et al.: "Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk", Breast Cancer Res. 2010 Nov 18;12(6):R98. [Epub ahead of print]
• Farhat GN et al.: "Changes in Invasive Breast Cancer and Ductal Carcinoma In Situ Rates in Relation to the Decline in Hormone Therapy Use", J Clin Oncol. 2010 Nov 8. [Epub ahead of print]
• Rijnsburger AJ et al.: "BRCA1-Associated Breast Cancers Present Differently From BRCA2-Associated and Familial Cases: Long-Term Follow-Up of the Dutch MRISC Screening Study", J Clin Oncol. 2010 Nov 15. [Epub ahead of print]
• FH01 collaborative teams: "Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study", Lancet Oncol 2010 Nov 17. [Epub ahead of print]

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• Champion L et al.: "Breast cancer recurrence diagnosis suspected on tumor marker rising: value of whole-body 18FDG-PET/CT imaging and impact on patient management", Cancer. 2010 Nov 8. [Epub ahead of print]
• Stopeck AT et al.: "Denosumab Compared With Zoledronic Acid for the Treatment of Bone Metastases in Patients With Advanced Breast Cancer: A Randomized, Double-Blind Study", J Clin Oncol. 2010 Nov 8. [Epub ahead of print
• Liang K et al.: "Recombinant Human Erythropoietin Antagonizes Trastuzumab Treatment of Breast Cancer Cells via Jak2-Mediated Src Activation and PTEN Inactivation", Cancer Cell. 2010 Nov 16;18(5):423-35
• Phillips KA et al.: "Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trial", Breast Cancer Res Treat. 2010 Nov 3. [Epub ahead of print]
• Onishi T et al.: "Non-Sentinel Lymph Node Status and Prognosis of Breast Cancer Patients with Micrometastatic Sentinel Lymph Nodes", Eur Surg Res. 2010 Nov 22;45(3-4):344-349. [Epub ahead of print]
• Ward ST et al.: "A two-millimetre free margin from invasive tumour minimises residual disease in breast-conserving surgery", Int J Clin Pract. 2010 Nov;64(12):1675-80
• McCarthy CM et al.: "Patient satisfaction with postmastectomy breast reconstruction: a comparison of saline and silicone implants", Cancer. 2010 Nov 8. [Epub ahead of print]
• Gahm J et al.: "Bilateral prophylactic mastectomy in women with inherited risk of breast cancer - Prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery", Breast 2010 Dec:19(6):462-9
• Salkowski LR et al.: "Utility of 6-month Follow-up Imaging after a Concordant Benign Breast Biopsy Result", Radiology. 2010 Nov 15. [Epub ahead of print]
• Lacroix AZ et al.: "Breast Cancer Incidence in the Randomized PEARL Trial of Lasofoxifene in Postmenopausal Osteoporotic Women", J Natl Cancer Inst. 2010 Nov 4. [Epub ahead of print]

Comment

• "Effectiveness of mammography screening for women ages 40 to 49 years" - Barbro Hellquist, Department of Radiation Sciences, Umeå University, Umeå, Sweden
   
  "Though consensus has been reached that mammography screening can reduce mortality and is efficient for women age 50-69, the effectiveness for women age 40-49 is still questioned. The results of RCTs and Meta-analyses have been conflicting. There are few studies of the effectiveness of service-screening for the age group 40-49.
  In the SCRY study, which is the largest for the age group to date including all of Sweden for an average follow-up of 16 years, mammography screening for women aged 40-49 was shown to be effective for reducing breast cancer mortality "  
  (Comment on:  Hellquist BN et al.: "Effectiveness of population-based service screening with mammography for women ages 40 to 49 years: evaluation of the Swedish Mammography Screening in Young Women (SCRY) cohort", Cancer. 2010 Oct 1 [Epub ahead of print])

    What do you think about about mammography screening for women ages 40 to 49 years? Share your opinion on LinkedIn®  

Press Releases

• "Smoking Increased Risk of Death in Women With Breast Cancer" - American Association for Cancer Research - www.aacr.org  
• "FDA approves new treatment option for late-stage breast cancer" - U.S. Food and Drug Administration, www.fda.gov

Calendar of Events

• 33rd San Antonio Breast Cancer Symposium - Dec 8-12, 2010 , San Antonio, TX, USA

Fragments of History

• Leonides (2^nd century AD), a surgeon of the Alexandrian school, was the first to note that breast cancers spread to the axilla

Best Study of the Month

• Mahon FX et al.: "Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial", Lancet Oncol. 2010 Nov;11(11):1029-1035

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Literature Selection

• Schultz C et al.: "Hearing loss and complaint in patients with head and neck cancer treated with radiotherapy", Arch Otolaryngol Head Neck Surg. 2010 Nov;136(11):1065-9
• Zhang CH et al.: "Effects of interferon treatment on development and progression of hepatocellular carcinoma in patients with chronic virus infection: A meta-analysis of randomized controlled trials", Int J Cancer. 2010 Nov 12. [Epub ahead of print]
• Michaud DS et al.: "Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study", Am J Clin Nutr. 2010 Nov;92(5):1145-50
• Bakhru A et al.: "Casting light on 25-hydroxyvitamin D deficiency in ovarian cancer: a study from the NHANES", Gynecol Oncol. 2010 Nov;119(2):314-8
• Rubenstein JH et al.: "Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux", Aliment Pharmacol Ther. 2010 Nov;32(10):1222-7
• Din FV et al.: "Effect of aspirin and NSAIDs on risk and survival from colorectal cancer", Gut. 2010 Dec;59(12):1670-9
• Gillessen S et al.: "Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer", J Natl Cancer Inst. 2010 Nov 10. [Epub ahead of print]
• Kubicek GJ et al.: "PSA decrease during combined-modality radiotherapy predicts for treatment outcome", Int J Radiat Oncol Biol Phys. 2010 Nov 1;78(3):759-62
• Williams SB et al.: "Radical Retropubic Prostatectomy and Robotic-assisted Laparoscopic Prostatectomy: Likelihood of Positive Surgical Margin(s", Urology. 2010 Nov;76(5):1097-101
• Villavicencio H et al.: "Bladder preservation strategy based on combined therapy in patients with muscle-invasive bladder cancer: management and results at long-term follow-up", Urol Int. 2010;85(3):281-6