Whole breast proton irradiation in women with breast cancer

 

 

 


When using radiotherapy for left-sided breast cancer a breath-hold technique can be used to decrease the dose in the heart. However, due to anatomical variations in some patients, the radiation dose to the heart remains relatively high, even with the use of advanced photon-based techniques. In a radiotherapy planning study, in which 20 left-sided breast cancer patients were included, we noted that intensity modulated proton therapy (IMPT), when compared to intensity modulated  radiotherapy (IMRT; i.e. photon therapy), enabled better sparing of the heart, even without using a breath-hold technique. In the majority of the IMPT cases, a reduction to almost zero to the heart was obtained. However, as IMPT for breast cancer is currently not widely available, IMPT should be reserved for patients remaining at high risk for major coronary events.

     

     

    Bibliographic Reference:

Mast ME et al.: "Whole breast proton irradiation for maximal reduction of heart dose in breast cancer patients", Breast Cancer Res Treat. 2014 Nov;148(1):33-9

     

     

     

     

     

    Mirjam Mast 
    Radiotherapy Centre West, The Hague, The Netherlands